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The Relational Sequencing TB Knowledgebase (ReSeqTB) is a one stop source of curated, aggregated, genotypic and phenotypic information and associated metadata from Mycobacterium tuberculosis (Mtb) strains.

The ReSeqTB platform incorporates a standardized, validated whole genome sequencing (WGS) pipeline and a customizable targeted sequence analysis (TSA) pipeline.

The knowledgebase will inform the development of probe-based and next generation sequencing (NGS) assays for interpreting drug resistance / susceptibility and enable large-scale drug resistance surveillance and support clinical decision making for TB patient management.

ReSeqTB provides the content on this website as a free resource to the global TB community. This content has not been evaluated by stringent regulatory authorities and is not intended to be used for patient management.

The February 2019 resistance report is now available based on the analysis of over 7500 isolates (nearly twice as many as the previous report). An analysis of the “summary of the changes” between the two reports is also available. Overall there were:

        • 47 additional new graded mutations associated with drug resistance
        • 33 additional mutations not associated with drug resistance
        • 9 mutations received an upgraded score
        • 1 mutation received a downgraded score
        • 4 mutations reverted to indeterminant

ReSeqTB Basic Access Site

  • Sign up now to access ReSeqTB data, bioinformatics tools, and reports.
  • This data contains all curated, aggregated genotypic and phenotypic information for publicly available sequences.
  • Visualization and analytic tools available for your use.
  • Aggregated data reports of the entire platform can also be downloaded as well as the most recent mutation interpretation table.
  • The user only needs a simple registration to access the site.

Full-Access ReSeqTB Data Platform

  • Once logged into the public site, links are provided to direct you to the full ReSeqTB platform.
  • This platform contains both public data as well as additional limited-access data contributed to the platform.
  • This restricted site has limited access set by the contributors.
  • Applications to the full-access site is restricted to current CPTR members and ReSeqTB data contributors. Due to the presense of regulated and clinical information, two-factor authentication is required when signing in to the restricted platform for data compliance. Please contact Marco Schito ( if you want to explore access to the private database.